This blog intends to create an educational platform for Emergency Physicians, sharing EM related basics and updates. Every week, I come up with a new post which can be in the form of written material with references/other FOAMed resources OR a 15-20 minute podcast with a written summary. My goal with this blog is to improve Resident education, Academic EM and Flipping the classroom. To get the maximum benefit from this blog, subscribe by your e-mail.
I have completed bits of my EM training from India. Currently I am boarded with credentials from Christian Medical College, Vellore and also from the prestigious Royal College of Emergency Medicine, UK. I am currently working in London as an A&E doctor, trying to appreciate the differences in the practise and culture of Emergency Medicine across different healthcare systems. I have always been an avid FOAMed supporter because FOAMed played an indispensable role during the days of my initial training. Through this blog, I aspire to disseminate knowledge and stay up to date with the EM literature.
Proton Pump Inhibitors and Anti-emetic Cocktail - A remedy for all
A blend of Proton Pump Inhibitor and anti emetics is something that a bulk of patients get, sometimes without a reason. I think it is time to step back and always question ourselves prior to ordering these medications. More importantly, we need to get rid of the thought that pushes us to prescribe thinking that "if there is no benefit, they are probably not going to hurt". Let us look at some possible downsides of these drugs.
Proton Pump Inhibitors
They are used for a myriad of concerns such as headache, vomiting, nausea, abdominal pain (regardless of presumed etiology), eradicate H. Pylori, ZE Syndrome, gastroenteritis, GERD and so on.. While a single dose may not have much side effects but in the long run, there are potential downsides that might accompany these medications. In addition, these are freely available as over the counter preparations and therefore, have the possibility of being misused.
Possible Adverse Effects with long term use (other than GI Distress and Headache)
1. Hypocalcemia, Osteoporosis and Fractures Probably because dietary calcium absorption is dependent upon an acidic environment in the gut.
2. Hypomagnesemia (May present as arrhythmias)
3. Anemia (B12 and Iron deficiency)
PPIs may also affect vitamin B12 levels because the body can’t absorb the vitamin without stomach acid to uncouple the vitamin from protein in food.
It is unlikely that patients with normal iron stores will develop iron deficiency anemia from PPI use alone. However, patients with low baseline iron stores may be more susceptible to further iron depletion with concurrent PPI therapy.
4. Increased risk of infections (Pneumonia and Clostridium Difficle)
PPIs blunt the gastric acid secretion that act as a defense mechanism against enteric bacteria. Increased gastric pH during PPI use allows for colonization of opportunistic microbes)
5. Alters the composition of gut flora
6. Interact with Clopdrogel(click here to read more on this interaction)
PPI therapy in combination with clopidogrel (Plavix) use may increase the risk of cardiac events.
Ondansetron (AKA Emeset, Zofer, Zofran)
It is a 5HT3 receptor antagonist that is frequently used for Postoperative and Chemo Induced Nausea Vomiting , also prescribed for N&V in general and gastroenteritis. It is metabolised by liver.
Concerning Adverse Effects
Headache, Dizziness, Fever
Serotonin Syndrome (with concomitant use of serotonergic meds)
1Hutchinson C, Geissler CA, Powell
JJ, Bomford A. Proton pump inhibitors suppress absorption of dietary non-haem
iron in hereditary haemochromatosis. Gut. 2007;56(9):1291–1295.
2Ito T, Jensen RT (2010). "Association
of long-term proton pump inhibitor therapy with bone fractures and effects on
absorption of calcium, vitamin B12, iron, and
magnesium". Current Gastroenterology Reports12(6):
3Focks JJ, Brouwer MA, van Oijen MG,
Lanas A, Bhatt DL, Verheugt FW (2013). "Concomitant
use of clopidogrel and proton pump inhibitors: impact on platelet function and
clinical outcome- a systematic review". Heart99(8):
4 Cardoso RN, Benjo AM,
DiNicolantonio JJ, Garcia DC, Macedo FY, El-Hayek G, et al. (2015). "Incidence
of cardiovascular events and gastrointestinal bleeding in patients receiving
clopidogrel with and without proton pump inhibitors: an updated
meta-analysis". Open Heart2 (1):
5 Lambert AA, Lam JO, Paik JJ,
Ugarte-Gil C, Drummond MB, Crowell TA (2015). "Risk of
community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a
systematic review and meta-analysis". PLoS ONE10 (6):
6Corleto VD et al. Proton pump
inhibitor therapy and potential long-term harm. Current Opinion in
Endocrinology, Diabetes and Obesity. 2014 February;21(1):3-8. doi:10.1097/MED.0000000000000031PMID 24310148
7 US Food and Drug
Administration. (2012). FDA Drug Safety Communication: New information
regarding QT prolongation with ondansetron (Zofran). Retrieved from http://www.fda.gov/Drugs/DrugSafety/ucm310190.htm
8Gollapudy, Suneeta, Vikram Kumar,
and M. Saeed Dhamee. "A case of serotonin syndrome precipitated by
fentanyl and ondansetron in a patient receiving paroxetine, duloxetine, and
bupropion." Journal of clinical anesthesia 24.3 (2012):